师资队伍

个人介绍

博士，教授，山东青岛人。2011—2018年就读于浙江工业大学，先后获得学士、硕士学位。2018年获国家留学基金委公派留学奖学金，赴德国格赖夫斯瓦尔德大学（University of Greifswald）Bornscheuer教授课题组攻读博士学位，并于2022年底获得博士学位。随后进入浙江工业大学郑裕国院士课题组开展博士后研究工作，2026年起任职于安徽师范大学。长期从事合成生物学酶工程领域研究，主要围绕转氨酶和细胞色素P450单加氧酶（Cytochrome P450）的结构解析、催化机制及酶工程改造开展研究，在酶催化机制解析与生物催化应用方面取得系列创新成果。

主讲课程

酶工程、基因工程、生物化学

研究方向

合成生物学、生物催化、酶催化

项目情况

参与国家自然科学基金面上项目“腈水解酶的自组装过程及超分子结构催化机理的研究”（项目编号：22378361，2024—2027）

浙江省博士后择优资助

获奖情况

2023年入选国家级海外高层次人才引才项目“博士后专项”

第一届“工行杯”浙江省博士后创新创业大赛创新赛铜奖

论文专利

1. Chao Xiang; Jia-Jia Mou; Yue Jiang; Yu-Ke Cen; Ya-Ping Xue; Yu-Guo Zheng; Design-informed construction of self-sufficient cytochrome P450 fusion enzymes for efficient avermectin oxidation, International Journal of Biological Macromolecules, 2026, 351: 151151.

2. Chao Xiang; Yu-Ke Cen; Ya-Ling Yi; Lu-Lu Zhang; Ya-Ping Xue; Yu-Guo Zheng; Avermectins and their derivatives: recent advances in biosynthesis and application, Journal of Agricultural and Food Chemistry, 2025, 73: 1757-1774.

3. Chao Xiang; Yu-Ke Cen; Ya-Ping Xue; Yu-Guo Zheng; The pedal-like loop of (R)-selective transaminases plays a critical role to the functionality of the enzyme, Biotechnology letters, 2025; 47:35.

4. Yu-Ke Cen; Lin Zhang; Yue Jiang; Xiang-Fu Meng; Yuan Li; Chao Xiang; Ya-Ping Xue; Yu-Guo Zheng; Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield, Organic Biomolecular Chemistry, 2024, 22: 3009–3018.

5. Yu-Fei Ao; Shu-Xin Pei; Chao Xiang; Marian J. Menke; Lin Shen; Cheng-Hai Sun; Mark Dörr; Stefan Born; Matthias Höhne; Uwe Bornscheuer, Structure‐ and data‐driven protein engineering of transaminases for improving activity and stereoselectivity, Angewandte Chemie International Edition, 2023, 62: e202301660.

6. Shuke Wu^#; Chao Xiang^#; Yi Zhou; Mohammad Saiful Hasan Khan; Weidong Liu; Christian G.Feiler; Ren Wei; Gert Weber; Matthias Höhne; Uwe T. Bornscheuer ; A growth selection system for the directed evolution of amine-forming or converting enzymes, Nature Communications, 2022, 13(1): 7458.

7. Chao Xiang; Yu-Fei Ao; Matthias Höhne; Uwe T. Bornscheuer; Shifting the pH Optima of (R)-Selective Transaminases by Protein Engineering, International Journal of Molecular Sciences, 2022, 23(23): 15347.

8. Chao Xiang; Shuke Wu; Uwe T. Bornscheuer; Directed evolution of an amine transaminase for the synthesis of an Apremilast intermediate via kinetic resolution, Bioorganic & Medicinal Chemistry, 2021, 43: 116271.

9. Moritz Voss^#; Chao Xiang^#; Jérémy Esque; Alberto Nobili; Marian J.Menke; Isabelle André; Matthias Höhne; Uwe T.Bornscheuer ; Creation of (R)-amine transaminase activity within an α-amino acid transaminase scaffold, ACS Chemical Biology, 2020, 15(2): 416-424.

10. Feng Cheng; Chao Xiang; Xiao-Jian Zhang; Zhi-Qiang Liu; Yu-Guo Zheng; ReToAd: simple method for the rapid replacement of promoters to improve protein production, 2018, Biotechnology letters, 40: 957-964.