师资队伍

个人介绍

何心伟，副教授，博士生导师。2003年7月本科毕业留校工作，2018年3月-2019年3月赴香港中文大学化学系访学，合作导师：Kwong Fuk Yee教授。近年来主持省部级项目2项，教育厅重点项目2项，省重点实验室开放课题2项，企业委托技术开发项目1项。科研成果获安徽省科学技术奖三等奖1项，在Chem. Sci., Org. Lett., Chem. Commun., Adv. Synth. Catal., Sci. China Chem.等期刊发表SCI研究论文90余篇，获授权国家发明专利8项。教学上获安徽省普通高校青年教师教学竞赛一等奖，安徽省“教坛新秀”称号等。

主讲课程

化工原理、化工安全与环境、化工基础、材料工程基础

研究方向

主要研究领域为有机合成方法学，研究工作主要包括：

(1) 含氧/含氮杂环化合物的设计与合成

(2) 过渡金属催化C-H键官能化

(3) 有机荧光分子的设计合成及性能研究

(4) 重氮化合物和邻炔亚甲基苯醌(o-AQMs)的多样性化转化

项目情况

1. UV固化技术在PU合成革上的应用研究(企业委托技术开发项目)，杭州卡洛实业有限公司(2025091)，2025.6-2028.5.

2. N-磺酰基-1,2,3-三氮唑与烯胺酮的区域选择性串联环化反应研究，安徽省高等学校自然科学研究重点项目 (2022AH050210)，2023.1-2025.12.

3. 基于苯丙炔胺类化合物的亲核取代-分子内环化串联反应研究，安徽省自然科学基金面上项目 (1808085MB41)，2018.7-2021.6.

4. 基于叠氮化合物和炔烃的多组分反应研究，安徽省高等学校自然科学研究重点项目 (KJ2016A267)，2016.1-2017.12.

5. FeCl₃催化的串联反应合成香豆素类化合物的应用研究，安徽省自然科学基金青年基金项目 (1308085QB39)，2013.7-2015.5.

获奖情况

2026年获安徽师范大学第六届教学创新大赛二等奖

2021年获安徽师范大学“优秀共产党员”称号

2019年获安徽省“教坛新秀”称号

2019年获安徽师范大学首届“郭锐评、陈礼勤奖教金”突出贡献奖

2019年获安徽省第四届普通高校青年教师教学竞赛一等奖

2018年获安徽省科学技术奖三等奖

2015年获安徽省第八届自然科学优秀学术论文三等奖

2012年获安徽省第七届自然科学优秀学术论文三等奖

论文专利

代表性论文：

1. Wangcheng Hu, Miaomiao Chen, Xinyu Tong, Qiang Tang, Yongjia Shang,* Xinwei He.* Rhodium(III)-Catalyzed [3+2] Annulation of Diazo Compounds with Enaminones for Constructing Polysubstituted NH-Pyrroles. Org. Lett., 2026, 28, DOI: 10.1021/acs.orglett.6c02455.

2. Yanan Liu, Qiang Tang, Pui Ying Choy, Yangzilin Kong, Ni Gu, Susuo Lu, Yongjia Shang,* Fuk Yee Kwong,* Xinwei He.* Divergent Three-Component Assembly of Densely Functionalized Dibenzofurans via ZnCl₂-Mediated Cascade Annulation. Org. Lett., 2026, 28, DOI: 10.1021/acs.orglett.6c02234.

3. Yanan Liu, Pui Ying Choy, Qiang Tang, Mengdi Wu, Yangzilin Kong, Yongjia Shang,* Fuk Yee Kwong,* Xinwei He.* A Palladium-Catalyzed Cascade Double Annulation Strategy for Modular Access to Dihydrocyclopenta[b]chromenes. Org. Lett., 2025, 27, 8405-8410.

4. Lvlv Gao, Jianwei Wu, Jian Wang, Enshen Zhang,* Yongjia Shang, Xinwei He.* Direct Access to Aminocyclopentenones through Rh-catalyzed Cascade Wolff Rearrangement and Decarbonylative Amination. Adv. Synth. Catal., 2025, 367, e70110.

5. Qiang Tang,* Yannan Liu, Mengdi Wu, Yangzilin Kong, Xiaochun Jiang, Shizhang Ling,* Yongjia Shang,* Xinwei He.* NaHCO₃-promoted Formal [4+3] Annulation of Salicylaldehydes with Isoquinolinium Salts Accessing Isoquinoline-fused Benzo[f][1,3]oxazepines. Adv. Synth. Catal., 2025, 367, e202401295.

6. Mengdi Wu, Yanan Liu, Yangzilin Kong, Binbin Fei, Qiang Tang,* Xinwei He.* One-pot Transformation Strategy of o-Hydroxyphenyl Propargylamines for Modular Acess to 3-Functionalized Benzofurans. Adv. Synth. Catal., 2025, 367, e202400893.

7. Qi Li, Xin-Yu Song, Zi-Xin Wu, Ling Li,* Ting-Ting Zhu, Xinwei He,* Chuan-Jin Hou.* Chiral P,N,N-Ligands for the Manganese-Catalyzed Asymmetric Formal Hydroamination of Allylic Alcohols. J. Org. Chem., 2025, 90, 11904-119097.

8. Qiang Tang, Yanan Liu, Binbin Fei, Qianqian Tao, Chen Wang, Xiaochun Jiang,* Xinwei He,* Yongjia Shang.* Base-Mediated Cascade Lactonization/1,3-Dipolar CycloadditionPathway for the One-Pot Assembly of Coumarin-Functionalized Pyrrolo[2,1‑a]isoquinolines. J. Org. Chem., 2024, 89, 8420-8434.

9. Yinsong Wu, Yanan Liu, Yangzilin Kong, Mengdi Wu, Demao Wang, Yongjia Shang,* Xinwei He.* Modular Assembly of Pyrrolo[3,4-c]isoquinolines through Rh-Catalyzed Cascade C-H Activation/Annulation of O-Methyl Aryloximes with Maleimides. J. Org. Chem., 2024, 89, 8447-8457.

10. Hao Wu+, Shuguang Chen+,* Chunni Liu, Quansheng Zhao, Zhen Wang, Qiren Jin, Shijie Sun, Jing Guo, Xinwei He, Patrick J Walsh,* Yongjia Shang.* Construction of C-S and C-Se Bonds from Unstrained Ketone Precursors under Photoredox Catalysis. Angew. Chem. Int. Ed., 2024, 63, e202314790.

11. Yanan Liu, Pui Ying Choy, Demao Wang, Mengdi Wu, Qiang Tang, Xinwei He,* Yongjia Shang,* Fuk Yee Kwong.* Cascade Annulation Strategy for Expeditious Assembly of Hydroxybenzo[c]chromen-6-ones and Their Photophysical Property Studies. J. Org. Chem., 2023, 88, 16609-16620.

12. Xinwei He,* Ruxue Li, Pui Ying Choy, Jiahui Duan, Zhenzhen Yin, Keke Xu, Qiang Tang, Rong-Lin Zhong, Yongjia Shang,* Fuk Yee Kwong.* An expeditious FeCl₃-catalyzed cascade 1,4-conjugate addition/annulation/1,5-H shift sequence for modular access of all-pyrano-moiety-substituted chromenes. Chem. Sci., 2022, 13, 13617-13622.

13. Tianyi Liu, Kin Boon Gan, Rong-Lin Zhong, Xinwei He,* Fuk Yee Kwong.* A Metal-Free and Redox-Neutral Benzylic C-O Cyclization for Succinct Access of Helical Chromenes. Org. Lett., 2022, 24, 6805-6809.

14. Qiang Tang, Keke Xu, Xinwei He,* Yongjia Shang.* Metal-Free Cascade 1,4-Conjugate Addition/Selective Annulation Strategy for Divergent Synthesis of Polysubstituted Imidazoles and 4-Alkenylquinazolines. Adv. Synth. Catal., 2022, 364, 4103-4109.

15. Wenbo Hu, Liqin Yan, Youpeng Zuo, Shuwen Kong, Yue Pu, Qiang Tang, Xinyu Wang, Xinwei He,* Yongjia Shang.* Rhodium(III)-Catalyzed Three-Component Cascade Annulation for Modular Assembly of N-Alkoxylated 3-Arylisoindolin-1-ones with Tetrasubstituted Carbon Center. Adv. Synth. Catal., 2022, 364, 2589-2595.

16. Jiahui Duan, Xinwei He,* Pui Ying Choy, Qi Wang, Mengqing Xie, Ruxue Li, Keke Xu, Yongjia Shang,* Fuk Yee Kwong.* Cascade Lactonization/Benzannulation of Propargylamines with Dimethyl 3-Oxoglutarate for Modular Assembly of Hydroxylated/Arene-Functionalized Benzo[c]chromen-6-ones. Org. Lett., 2021, 23, 6455-6460.

17. Xinwei He,* Ruxue Li, Pui Ying Choy, Mengqing Xie, Jiahui Duan, Qiang Tang, Yongjia Shang,* Fuk Yee Kwong.* A Cascade Double 1,4-Addition/Intramolecular Annulation Strategy for Expditious Assembly of Unsymmetrical Dibenzofurans. Commun. Chem., 2021, 4, 42.

18. Yinsong Wu, Xinwei He,* Mengqing Xie, Ruxue Li, Yi Ning, Jiahui Duan, Enshen Zhang, Yongjia Shang.* Rh(III)-Catalyzed Cascade Nucleophilic Addition/Annulation of 2‑Diazo-1,3-diketones with 1,3-Dicarbonyl Compounds To Access 6,7-Dihydrobenzofuran-4(5H)-ones. J. Org. Chem., 2021, 86, 7370-7380.

19. Li-Qin Yan, Zhenzhen Yin, Xinwei He,* Qianqian Li, Ruxue Li, Jiahui Duan, Keke Xu, Qiang Tang, and Yongjia Shang.* Copper-Catalyzed Cascade 1,4-Addition/Annulation/Hydrolysis of Propargylamines with 2-Hydroxynaphthalene-1,4-diones: Direct Formation of 12-Phenacyl-11H-benzo[b]xanthenes. J. Org. Chem., 2021, 86, 4182-4192.

20. Youpeng Zuo, Xinwei He,* Qiang Tang, Wangcheng Hu, Tongtong Zhou, Wenbo Hu, Yongjia Shang.* Palladium-Catalyzed 5-exo-dig Cyclization Cascade, Sequential Amination/Etherification for Stereoselective Construction of 3-Methyleneindolinones. Adv. Synth. Catal., 2021, 363, 2117-2123.

21. Tongtong Zhou, Xinwei He,* Youpeng Zuo, Yuhao Wu, Wangcheng Hu, Shiwen Zhang, Jiahui Duan and Yongjia Shang.* Rh-catalyzed formal [3+2] cyclization for synthesis of 5-aryl-2-(quinolin-2-yl)oxazoles and its applications in metal ions probes. Chin. J. Chem., 2021, 39, 621-626.

22. Xinwei He,* Ruxue Li, Pui Ying Choy, Tianyi Liu, Junya Wang, On Ying Yuen, Man Pan Leung, Yongjia Shang, Fuk Yee Kwong.* DMAP-Catalyzed Annulation Approach For Modular Assembly of Furan-Fused Chromenes. Org. Lett., 2020, 22, 9444-9449.

23. Xinwei He,* Ruxue Li, Pui Ying Choy, Tianyi Liu, On Ying Yuen, Man Pan Leung, Yongjia Shang, Fuk Yee Kwong.* Rapid Access of Alkynyl and Alkenyl Coumarins via a Dipyridinium Methylide and Propargylamine Cascade Reaction. Org. Lett., 2020, 22, 7348-7352.

24. Xinwei He,* Mengqing Xie, Ruxue Li, Pui Ying Choy, Qiang Tang, Yongjia Shang, Fuk Yee Kwong.* Organocatalytic Approach for Assembling Flavanones via a Cascade 1,4-Conjugate Addition/oxa-Michael Addition between Propargylamines with Water. Org. Lett., 2020, 22, 4306-4310.

25. Youpeng Zuo, Xinwei He,* Qiang Tang, Wangcheng Hu, Tongtong Zhou, Yongjia Shang.* Palladium-Catalyzed Cascade Decarboxylative Amination/6-endo-dig Benzannulation of o-Alkynylarylketones with N-Hydroxyamides To Access Diverse 1-Naphthylamine Derivatives. Org. Lett., 2020, 22, 3890-3894.

26. Xinwei He, Pui Ying Choy, Man Pan Leung, On Ying Yuen, Tianyi Liu, Yongjia Shang, Fuk Yee Kwong.* A ZnI₂-Catalyzed Regioselective Cascade 1,4-Conjugate Addition/5-exo-dig Annulation Pathway for One-Pot Access to Heterobiaryl Frameworks. Chem. Commun., 2019, 55, 15069-15072.

27. Xinwei He,* Mengqing Xie, Qiang Tang, Youpeng Zuo, Ruxue Li, and Yongjia Shang.* Catalyst-Free Synthesis of 2,3-Dihydrobenzofurans via a Formal [4+1] Annulation of Propargylamines with Sulfur Ylides. J. Org. Chem., 2019, 84, 11623-11638.

28. Qianqian Li, Xinwei He,* Jiajia Tao, Mengqing Xie, Hui Wang, Ruxue Li, and Yongjia Shang.* Base-mediated 1,4-Conjugate Addition/Intramolecular 5-exo-dig Annulation of Propargylamines with Benzoylacetonitriles and β-Keto Esters for Polysubstituted Furans and Furo[3,4-c]coumarins Formation. Adv. Synth. Catal., 2019, 361, 1874-1886.

29. Xinwei He, Yongjia Shang,* Zhiyu Yu, Mei Fang, Yao Zhou, Guang Han, Fuli Wu. FeCl3-Catalyzed Four-component Nucleophilic Addition/Intermolecular Cyclization Yielding Polysubstituted Pyridine Derivatives. J. Org. Chem., 2014, 79, 8882-8888.

30. Xinwei He, Yongjia Shang,* Jinsong Hu, Kai Ju, Wei Jiang, Sufang Wang. Syntheses of N-sulfonyl-N,N-disubstitutedAmidines via a Three-component Free-radical Coupling Reaction of Tertiary Amines and Arenesulfonyl Azides with Terminal Alkynes, Sci. China Chem., 2012, 55, 214-222.

授权发明专利：

1. 何心伟，李如雪. 呋喃并[2,3-c]色烯衍生物及其制备方法，专利号: 202010139093.1，公开日: 2020.05.29.

2. 何心伟，李如雪，谢梦情. 二苯并呋喃衍生物及其制备方法，专利号: 202010141681.9，公开日: 2020.05.22.

3. 李欠欠，何心伟，陶佳佳，商永嘉. 多取代呋喃衍生物及其制备方法，专利号: 201810227907.X, 公开日: 2018.08.24.

4. 武玉豪，何心伟，左有鹏，商永嘉. 香豆素-4-磺酸酯衍生物及其制备方法， 专利号: 201810034868.1, 公开日: 2018.07.20.

5. 左有鹏，何心伟，商永嘉. 异香豆素衍生物的制备方法，专利号: 201710416486.0, 公开日: 2017.09.01.

6. 何心伟，靳文静，陈娇娇，商永嘉. 一种香豆素-3-羧酸酯衍生物的制备方法.，专利号: 201310642930.2, 公开日: 2014.03.12.

7. 何心伟，商永嘉，琚凯. 3,4,5-三取代噁唑烷酮类化合物及其制备方法，专利号: 201410557565.X, 公开日: 2015.02.04.

专著：

1. Pui Ying Choy, Xinwei He, Fuk Yee Kwong.* Chapter 2: Palladacycles as Precatalysts for Heck and Sonogashira Cross-Coupling Reactions. Palladacycles: Catalysis and Beyond, Burlington: Elsevier, 2019. pp. 21-173.